CONSEQUENCES OF THE CORONAVIRUS INFECTION: THE POST-COVID SYNDROME AND MENTAL MANIFESTATIONS. LITERATURE REVIEW

Abstract

Introduction. The pathogenetic aspects of the inflammatory syndrome and complications after coronavirus infection have different development mechanisms. Patients who have had COVID-19, after recovery, experience fatigue, shortness of breath, central nervous system dysfunction and other extrapulmonary symptoms. The article describes the features of the course of various clinical disorders after suffering from COVID-19. In addition, some mechanisms for the development of long-term consequences are discussed. Aim. Conduct an analysis of the literature data on the pathogenesis, clinical manifestations and development of various manifestations of post-Covid syndrome, including cognitive impairment. Search strategy: Full-text publications in English and Russian that are devoted to the problem of COVID-19 were included in this review. The search for sources was carried out in the following databases: PubMed, The Cochrane Library, Scopus, Elsevier, and E-library; by keywords, (COVID-19, coronavirus infection, SARS-CoV-2, post-acute Covid syndrome, cognitive impairment) from 2019 to 2022. According to the topic of study, 712 publications have been reviewed, 81 of which met the selection criteria and were included in this review. Results. Numerous publications show that the range of clinical symptoms of post-Covid syndrome is wide. Research has identified the following mental consequences after a coronavirus infection: anxiety, memory and attention impairment, depression smell disorder, insomnia, debuts of known mental disorders. The global medical community has been introduced the concept of “long Сovid”, which combines subacute COVID-19 and post-Сovid syndrome. Thus, a more detailed study of this problem is relevant with the search for algorithms for providing effective medical care for coronavirus infection and postCOVID disorders.