PROGNOSTIC SIGNIFICANCE OF GENETIC TUMOR MARKERS IN THYROID NEOPLASMS: LITERATURE REVIEW

Abstract

Background. This review examines recent advances in the identification of molecular markers using next-generation sequencing and microarrays. The potential for using these tumor markers to differentiate the most common sporadic forms of thyroid cancer is presented and compared. Public databases with datasets obtained from high-throughput experiments are a valuable source of information that helps tumor marker research in general, including the identification of molecular signatures of thyroid tumors. The aim of this review is to analyze well-established tests with a special emphasis on the effective role of new potential thyroid tumor markers based on modern data on the molecular genetic mechanisms involved in the tumor process. Search strategy. To conduct the study, articles in the public domain were analyzed using the following databases and specialized search engines for scientific publications: PubMed, Web of Science, Scopus, Google Scholar, Cochrane Library. Inclusion criteria: publications with a high level of evidence (level A and B), including meta-analyses, systematic reviews and cross-sectional studies. Short reports and advertising articles were excluded. Results and conclusions. The literature review is devoted to the problem of prognostic significance of genetic tumor markers of thyroid gland tumors. Various types of tumor markers of thyroid gland tumors are presented, including tumor markers of benign neoplasms. The significance of tumor markers of thyroid gland tumors is substantiated.