BIOPOLYMER-BASED WOUND COATINGS, USED FOR WOUND HEALING. LITERATURE REVIEW.

Abstract

Introduction: post-traumatic, trophic and other wounds, the pathophysiological causes of which are a number of factors, are currently cured by standard methods of treatment, but it is necessary to take into account that the healing of such wounds, both in terms of area and time, patient comfort and from the economic point of view are not always optimal. In this regard, the development, modification and implementation of various types of wound coverings has recently become increasingly important. Purpose: To substantiate the efficacy of biopolymer-based wound dressings in the treatment of complicated infected wounds through a review of preclinical and clinical studies. Search strategy: A review of clinical and preclinical studies, reviews and meta-analyses of different types of biopolymerbased dressings, both in comparison with standard research methods and with each other, was conducted. Studies were searched in medical databases (PUBMED, MedLine, Scopus) over a five-year period (2018-2023). Key words in the search were WOUND, DRESSING, and BIOPOLYMERS. 176 articles describing the application of biopolymer coating dressings were found. 96 articles were rejected according to the exclusion criteria (lack of evidence, repetition of articles, or inconsistency with the specified subject matter). 80 articles meeting the inclusion criteria were accepted for analysis. Results. The researchers found that the use of wound coatings based on biopolymers is a more effective method of treatment of long non-healing wounds in comparison with standard methods of treatment, which was statistically proven, while comparing different types of dressings (based on chitosan, alginate, cellulose, collagen and their modifications) with each other, the bulk of studies proves that the use of all these dressings has a place, and there is no statistically proven difference in the effectiveness of their use. The considered pathologies that were presented in the articles belong to traumatology, combustiology, cosmetology, dentistry and general surgery. Conclusion: there is a large number of wound dressings that meet the requirements of specialists, however, at the moment there is no "ideal" dressing that meets all criteria at the same time and is widely available, and therefore, our literature review revealed that the use of wound dressings is more justified in comparison with the use of standard methods of treatment.