COMORBIDITY IN OSTEOARTHRITIS

Abstract

Introduction. Comorbid pathology, which accompanies most chronic non-communicable diseases, not only negatively 
affects the treatment of patients, but also significantly worsens their quality of life. Osteoarthritis (OA) is an age-related 
disease characterized by high comorbidity.
Aim: to identify the most common comorbid conditions in patients with OA. 
Materials and methods: Study Design: The study is prospective, controlled. The study period is from September 01 to 
December 01, 2022. in the KGP on the REM "City Polyclinic" No. 5. 60 patients with a reliable diagnosis of OA were 
examined, including 12 men (20%), 48 women (80%), mean age (63.37±10.1 years), mean duration of illness (6.89±7.45). 
All patients signed an informed consent prior to the start of the study. Statistical processing of the obtained data was carried 
out using the Statistica-6 program, where p<0.05 was considered significant. 
Results. Mostly dominated by women 86.7%, over 50 years old. Out of 60 patients with OA, gonarthrosis was detected 
in 44 (73.3%), coxarthrosis in 4 (6.7%), generalized form - in 12 (20%), with the prevalence of patients with X-ray stage II. All 
60 patients with OA had concomitant diseases, of which 92.2% had two or more comorbid pathologies. The leading place in 
the structure of comorbidity was occupied by pathology of the cardiovascular system in 31 (51.7%) patients, including arterial 
hypertension (AH) in 18 (58%) patients, coronary heart disease (CHD) in 13 (42%) patients, with this was dominated by 
angina pectoris II functional class. The mean systolic pressure at baseline and over time was 123.39±17.02 mm Hg. Art., 
indicators of diastolic pressure initially and in dynamics were within 82.62±5.05. In second place is endocrine pathology in 16 
(26.7%) patients. Six (10%) patients had osteoporosis (OP) and received bisphosphonates. 
Conclusions. Almost all OA patients have a comorbid pathology, while in 92.2% of cases patients have two or more 
concomitant diseases. The most common comorbidities are diseases of the cardiovascular system (51.7%, including 
hypertension in 58% of patients), diseases of the endocrine system in 16 patients (26.7%), of which obesity in 8 (50%), Type 
2 diabetes in 5 (31.3%), hypothyroidism in 3 (18.7%), respectively, and OP in 10% of patients.