INTERRELATION OF INTRAABDOMINAL HYPERTENSION AND MARKERS OF GASTROINTESTINAL TRACT INJURY IN PATIENTS WITH MULTIORGAN DYSFUNCTION

Abstract

Relevance. Intraabdominal hypertension syndrome is one of the main causes in the etiology of multiorgan dysfunction and high mortality of patients. It is relevant today to determine the level of the interrelation of various markers of bacterial translocation (presepsin and I-FABP) and IAH for the purpose of early diagnosis of complications since there are not enough studies. Aim: Analysis of available data on the correlation between IAH and bacterial translocation in various-genesis critically ill patients. Question: Is there a correlation between IAH and bacterial translocation markers in critically ill patients? Search strategy: Sources of information: Pubmed, Scopus, Google Scholar, Web of Science for the last 10 years (from 2013 to 2023). Inclusion criteria: all research papers that included patients with multiple organ dysfunction, abdominal hypertension, and surgical diseases of the gastrointestinal tract. Patients in intensive care units who underwent detection of bacterial translocation proteins, particularly, I-FABP, presepsin, and zonulin. In addition, experimental papers with animals using the same criteria over the past 10 years. Exclusion criteria: studies that were published before 2013, as well as studies that did not have the main search criteria (abdominal hypertension, multiple organ dysfunction, markers of bacterial translocation were not detected). Patients under 18 years of age, patients with bladder injury or cancer. Key requests: multiple organ dysfunction, abdominal hypertension, intra-abdominal hypertension syndrome, I-FABP, presepsin, zonulin, gastrointestinal diseases, sepsis, multiple organ failure. Considering the uniqueness of the study, 88 papers were identified and selected according to thе search strategy. Results: Presepsin levels vary in healthy patients, SIRS patients, and patients with diagnosed sepsis within the range of 258.7±92.53ng/L, 430.0±141.33ng/L, and 1,508.3±866.6ng/L, respectively. In patients with acute surgical diseases, the level of I-FABP protein is much higher than in patients of the control group. The relevance of determining the level of zonullin protein in the blood in patients with multiorgan dysfunction is controversial and requires further in-depth research. Conclusion: According to the study, the relationship between the level of intra-abdominal hypertension and the proteins presepsin and I-FABP was determined in patients with multi-organ dysfunction of various origins. Study levels of presepsin, zonullin and I-FABP proteins in patients with multiorgan dysfunction due to their minimally invasive nature and rapidness of execution, contribute to reducing the mortality rate from postoperative complications, as well as timely surgical treatment.