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THE ROLE OF ESSENTIAL AND TOXIC TRACE ELEMENTS IN THE DEVELOPMENT OF KIDNEY STONE DISEASE. LITERATURE REVIEW

Authors

DOI:

https://doi.org/10.34689/9xarwz97

Keywords:

kidney stone disease, essential trace elements, toxic trace elements, heavy metals

Abstract

Relevance. A literature review focused on the impact of essential and toxic trace elements on the development of kidney stone disease. Special attention is given to the relationship between trace element imbalance, mineral metabolism disorders, oxidative stress, and inflammatory processes, which play a key role in the mechanisms of stone formation. Search Strategy: A systematic search of scientific publications was conducted in the PubMed, Scopus, Web of Science, Google Scholar, and Science Direct databases. The search period covered 10 years. A total of 60 articles, containing data on the role of essential and toxic trace elements in the pathogenesis of kidney stone disease, were included in the analysis. Results: Data on the impact of essential trace elements (calcium, magnesium, zinc, selenium) and toxic metals (lead, cadmium, mercury, arsenic) on the stone formation processes are presented. It was found that trace element imbalance may contribute to disturbances in mineral metabolism, the development of oxidative stress, and inflammatory reactions, which play a key role in the pathogenesis of kidney stone disease. The findings confirm the significant involvement of trace elements in the mechanisms of urolith formation. Conclusion: Monitoring the levels of trace elements in the body and reducing exposure to toxic metals may contribute to the prevention of kidney stone disease. Further research is needed to develop effective prevention and treatment strategies, focusing on studying the mechanisms through which trace elements influence stone formation processes.

Author Biographies

  • Arailym Kanatbekova

    PhD Student of the Department of Physiological Disciplines named after T.A. Nazarova, NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: doctor_araika@mail.ru ; Phone: +7 775 792 11 50; ORCID: https://orcid.org/0000-0003-3007-9322; Semey, Kazakhstan.

  • Assiya Yessenbayeva

    PhD of the Department of Nursing NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: assiya. yessenbayeva@smu.edu.kz ; Phone: +7 777 236 1697; ORCID: https://orcid.org/0000-0001-6195-2142 ; Semey, Kazakhstan

  • Roza Buleukhanova

    Candidate of Medical Sciences, Professor of the Russian Academy of Natural Sciences, Director of the Medical Center LLP "Zhan-Er". Semey, Kazakhstan; E-mail: zhan-er@mail.kz; Phone: +7 777 742 0574; Semey, Kazakhstan. 

  • Gulnar Terlikbaeva

    Lecturer of the Department Pathological Physiology named after Professor A.N. Nurmukhambetov, NJSC "KazNMU named after S.D. Asfendiyarov", Almaty, Kazakhstan. E-mail: Terlikbaeva.gulnar@mail.ru; Phone: +7 777 964 7628; ORCID: https://orcid.org/0009-0004-5368-2129; Almaty, Kazakhstan. 

  • Gulbarshyn Mukasheva

    Senior Teacher of the Department of Epidemiology and Biostatistics, NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: gulbarshyn_1_12@mail.ru; phone +7 775 220 07 45, https://orcid.org/0000-0003-3490-5628; Semey, Kazakhstan;

  • Dinara Shagiyeva

    Assistant of the Department of Nursing, Candidate of Medical Sciences. NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: dinara.shagiyeva@smu.edu.kz ; Phone: +7 705 798 3724; ORCID: https://orcid.org/0009-0009-2278-9624; Semey, Kazakhstan

  • Merkhat Akkaliev

    PhD of the Department of Surgical Disciplines. NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: merchat_72@mail.ru; Phone: +77771539854; ORCID: https://orcid.org/0000-0003-3122-7411 ; Semey, Kazakhstan.

  • Bakytbek Apsalikov

    PhD, Associate Professor, Head of the Department of Clinical Oncology and Nuclear Medicine named after D.R. Mussinov. NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: bakytbek.apsalikov@smu.edu.kz; Phone: +7 705 225 2524; ORCID: https://orcid.org/0000-0001-6983-9224; Semey, Kazakhstan. 

  • Zhanna Kozykenova

    PhD, Associate Professor of the Department of Physiological Disciplines named after T.A. Nazarova, , NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: alicher-02@mail.ru ; Phone: +7 7775835617; ORCID: https://orcid.org/0000-0001-7420-2279 ;Semey, Kazakhstan.

  • Meruyert Massabayeva

    PhD, Associate Professor, Chief Researcher of the Center of Scientific Research Laboratory. NJSC "Semey Medical University", Semey, Kazakhstan; E-mail: meruyert.massabayeva@smu.edu.kz ; Phone: +7 700 777 0230; ORCID: https://orcid.org/0000-0001-8240-361X; Semey, Kazakhstan.

References

Kanatbekova A.K., Kozykenova Zh.U., Apsalikov B.A., Akkaliyev M.N., Shagiyeva D.Sh., Mukasheva G.D., Terlikbaeva G.A., Buleukhanova R.T., Yessenbayeva А.А., Massabayeva M.R. The role of essential and toxic trace elements in the development of kidney stone disease. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 179-187. doi 10.34689/SH.2024.27.2.020

Қанатбекова А.Қ., Козыкенова Ж.У., Апсаликов Б.А., Аккалиев М.Н., Шагиева Д.Ш., Мукашева Г.Д., Терликбаева Г.А., Булеуханова Р.Т., Есенбаева А.А., Масабаева М.Р. Роль эссенциальных и токсичных микроэлементов в развитии мочекаменной болезни. Обзор литературы // Наука и Здравоохранение. 2025. Vol.27 (2), С.179-187. doi 10.34689/SH.2025.27.2.020

Қанатбекова А.Қ., Козыкенова Ж.У., Апсаликов Б.А., Аккалиев М.Н., Шагиева Д.Ш., Мукашева Г.Д., Терликбаева Г.А., Булеуханова Р.Т., Есенбаева А.А., Масабаева М.Р. Эссенциалды және уытты микроэлементтердің несеп тас ауруы дамуындағы рөлі. Әдебиеттік шолу // Ғылым және Денсаулық сақтау. 2025. Vol.27 (2), Б. 179-187. doi 10.34689/SH.2025.27.2.020

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Published

2025-11-05

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Vol. 27 No. 2 (2025): Issue 2

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How to Cite

THE ROLE OF ESSENTIAL AND TOXIC TRACE ELEMENTS IN THE DEVELOPMENT OF KIDNEY STONE DISEASE. LITERATURE REVIEW. (2025). Рецензируемый медицинский научно-практический журнал «Наука и здравоохранение», 27(2), 179-187. https://doi.org/10.34689/9xarwz97

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